2021 - present
Fredericks MN, Kolodner Z, Waalkes A, Sawatzki K, Hao L, Long DR, Penewit K, Midkiff C, McCormick CJ, Beraki S, Edlefsen PT, Barrow J, Greninger A, Gale M, Blair R, Salipante S, Fuller DH, O'Connor MA, SIV/SARS-CoV-2 Coinfection in Rhesus Macaquesimpacts Viralshedding, Host Immunity, the Microbiome, and Viral Evolution. Available at SSRN: http://dx.doi.org/10.2139/ssrn.5163314
Tisoncik-Go J, Lewis TB, Whitmore LS, Voss K, Niemeyer S, Dai J, Kim P, Hubbell K, Iwayama N, Ahrens C, Wangari S, Murnane R, Edlefsen PT, Guerriero KA, Gale M Jr, Fuller DH, O'Connor MA. Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques. Front Immunol. Volume 16 - 2025. https://doi.org/10.3389/fimmu.2025.1535807
O'Connor MA, Hawman DW, Meade-White K, Leventhal S, Song W, Randall S, Archer J, Lewis TB, Brown B, Fredericks MN, Sprouse KR, Tunggal HC, Maughan M, Iwayama N, Ahrens C, Garrison W, Wangari S, Guerriero KA, Hanley P, Lovaglio J, Saturday G, Veesler D, Edlefsen PT, Khandhar AP, Feldmann H, Fuller DH, Erasmus JH. A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned. PLoS Pathog. 2023 Apr;19(4):e1011298. doi: 10.1371/journal.ppat.1011298. eCollection 2023 Apr. PubMed PMID: 37075079; PubMed Central PMCID: PMC10150980.
Tisoncik-Go J, Voss KM, Lewis TB, Muruato AE, Kuller L, Finn EE, Betancourt D, Wangari S, Ahrens J, Iwayama N, Grant RF, Murnane RD, Edlefsen PT, Fuller DH, Barber GN, Gale M Jr, O'Connor MA. Evaluation of the immunogenicity and efficacy of an rVSV vaccine against Zika virus infection in macaca nemestrina. Front Virol. 2023;3. doi: 10.3389/fviro.2023.1108420. Epub 2023 Feb 28. PubMed PMID: 37383986; PubMed Central PMCID: PMC10306241.
Walls AC, VanBlargan LA, Wu K, Choi A, Navarro MJ, Lee D, Avena L, Berrueta DM, Pham MN, Elbashir S, Kraft JC, Miranda MC, Kepl E, Johnson M, Blackstone A, Sprouse K, Fiala B, O'Connor MA, Brunette N, Arunachalam PS, Shirreff L, Rogers K, Carter L, Fuller DH, Villinger F, Pulendran B, Diamond MS, Edwards DK, King NP, Veesler D. Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice. Cell Rep. 2022 Aug 30;40(9):111299. doi: 10.1016/j.celrep.2022.111299. Epub 2022 Aug 15. PubMed PMID: 35988541; PubMed Central PMCID: PMC9376299.
Fuller DH, O'Connor MA. Letter to the Editor: Prior Infection with Coccidioidomycosis in Nonhuman Primates and Impact on Simian Immunodeficiency Virus Disease and Vaccine Immunogenicity. AIDS Res Hum Retroviruses. 2022 May;38(5):347-349. doi: 10.1089/AID.2021.0236. Epub 2022 Mar 22. PubMed PMID: 35172614; PubMed Central PMCID: PMC9131037.
Ulrich-Lewis JT, Draves KE, Roe K, O'Connor MA, Clark EA, Fuller DH. STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses. Front Immunol. 2022;13:861710. doi: 10.3389/fimmu.2022.861710. eCollection 2022. PubMed PMID: 35529875; PubMed Central PMCID: PMC9072870.
O'Connor MA, Erasmus JH, Randall S, Archer J, Lewis TB, Brown B, Fredericks M, Groenier S, Iwayama N, Ahrens C, Garrison W, Wangari S, Guerriero KA, Fuller DH. A Single Dose SARS-CoV-2 Replicon RNA Vaccine Induces Cellular and Humoral Immune Responses in Simian Immunodeficiency Virus Infected and Uninfected Pigtail Macaques. Front Immunol. 2021;12:800723. doi: 10.3389/fimmu.2021.800723. eCollection 2021. PubMed PMID: 34992610; PubMed Central PMCID: PMC8724308.
Walls AC, Miranda MC, Schäfer A, Pham MN, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shirreff L, Ferrell DE, Bowen J, Brunette N, Kepl E, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Sprouse KR, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, Leist SR, Martinez DR, Clark M, Tisch R, O'Hagan DT, Van Der Most R, Van Voorhis WC, Corti D, McLellan JS, Kleanthous H, Sheahan TP, Smith KD, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric RS, King NP, Veesler D. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. Cell. 2021 Oct 14;184(21):5432-5447.e16. doi: 10.1016/j.cell.2021.09.015. Epub 2021 Sep 15. PubMed PMID: 34619077; PubMed Central PMCID: PMC8440233.
O'Connor MA, Munson PV, Dross SE, Tunggal HC, Lewis TB, Osborn J, Peterson CW, Huang MW, Moats C, Smedley J, Jerome KR, Kiem HP, Bagley KC, Mullins JI, Fuller DH. A Gut Reaction to SIV and SHIV Infection: Lower Dysregulation of Mucosal T Cells during Acute Infection Is Associated with Greater Viral Suppression during cART. Viruses. 2021 Aug 14;13(8). doi: 10.3390/v13081609. PubMed PMID: 34452474; PubMed Central PMCID: PMC8402906.
Guerriero KA, Murnane RD, Lewis TB, Brown B, Baldessari A, Jeffery DA, Malinowski CM, Fuller DH, O'Connor MA. Recrudescence of Natural Coccidioidomycosis During Combination Antiretroviral Therapy in a Pigtail Macaque Experimentally Infected with Simian Immunodeficiency Virus. AIDS Res Hum Retroviruses. 2021 Jul;37(7):505-509. doi: 10.1089/AID.2020.0228. Epub 2021 Feb 23. PubMed PMID: 33356854; PubMed Central PMCID: PMC8260887.
Tunggal HC, Munson PV, O'Connor MA, Hajari N, Dross SE, Bratt D, Fuller JT, Bagley K, Fuller DH. Effects of therapeutic vaccination on the control of SIV in rhesus macaques with variable responsiveness to antiretroviral drugs. PLoS One. 2021;16(6):e0253265. doi: 10.1371/journal.pone.0253265. eCollection 2021. PubMed PMID: 34138927; PubMed Central PMCID: PMC8211199.
Klatt NR, Broedlow C, Osborn JM, Gustin AT, Dross S, O'Connor MA, Coronado E, Barnette P, Hensley-McBain T, Zevin AS, Muir R, Roederer A, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Manuzak JA. Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques. NPJ Vaccines. 2021 Mar 11;6(1):34. doi: 10.1038/s41541-021-00298-4. PubMed PMID: 33707443; PubMed Central PMCID: PMC7952719.lect
Walls AC, Fiala B, Schäfer A, Wrenn S, Pham MN, Murphy M, Tse LV, Shehata L, O'Connor MA, Chen C, Navarro MJ, Miranda MC, Pettie D, Ravichandran R, Kraft JC, Ogohara C, Palser A, Chalk S, Lee EC, Guerriero K, Kepl E, Chow CM, Sydeman C, Hodge EA, Brown B, Fuller JT, Dinnon KH 3rd, Gralinski LE, Leist SR, Gully KL, Lewis TB, Guttman M, Chu HY, Lee KK, Fuller DH, Baric RS, Kellam P, Carter L, Pepper M, Sheahan TP, Veesler D, King NP. Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2. Cell. 2020 Nov 25;183(5):1367-1382.e17. doi: 10.1016/j.cell.2020.10.043. Epub 2020 Oct 31. PubMed PMID: 33160446; PubMed Central PMCID: PMC7604136.
2016 - 2020
Green WR, O'Connor MA. HIV vaccines: Unmasking myeloid derived suppressor cells. EBioMedicine. 2020 Nov;61:103063. doi: 10.1016/j.ebiom.2020.103063. Epub 2020 Oct 7. PubMed PMID: 33038766; PubMed Central PMCID: PMC7553988.
lErasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH. An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates. Sci Transl Med. 2020 Aug 5;12(555). doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. PubMed PMID: 32690628; PubMed Central PMCID: PMC7402629.
Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA. Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology. J Virol. 2019 Sep 15;93(18). doi: 10.1128/JVI.00372-19. Print 2019 Sep 15. PubMed PMID: 31217249; PubMed Central PMCID: PMC6714786.
O'Connor MA, Munson PV, Tunggal HC, Hajari N, Lewis TB, Bratt D, Moats C, Smedley J, Bagley KC, Mullins JI, Fuller DH. Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques. AIDS Res Hum Retroviruses. 2019 Mar;35(3):295-305. doi: 10.1089/AID.2018.0184. Epub 2019 Jan 2. PubMed PMID: 30398361; PubMed Central PMCID: PMC6434588.
O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH. Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w. PubMed PMID: 30135445; PubMed Central PMCID: PMC6105614
O'Connor MA, Rastad JL, Green WR. The Role of Myeloid-Derived Suppressor Cells in Viral Infection. Viral Immunol. 2017 Mar;30(2):82-97. doi: 10.1089/vim.2016.0125. Epub 2017 Jan 4. Review. PubMed PMID: 28051364; PubMed Central PMCID: PMC5346953.
Smedley J, Macalister R, Wangari S, Gathuka M, Ahrens J, Iwayama N, May D, Bratt D, O'Connor M, Munson P, Koday M, Lifson J, Fuller DH. Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques. PLoS One. 2016;11(6):e0157535. doi: 10.1371/journal.pone.0157535. eCollection 2016. PubMed PMID: 27309717; PubMed Central PMCID: PMC4911112.
Before 2016
O'Connor MA, Vella JL, Green WR. Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency. J Gen Virol. 2016 Feb;97(2):509-522. doi: 10.1099/jgv.0.000260. Epub 2015 Aug 6. PubMed PMID: 26253145; PubMed Central PMCID: PMC5394747.
O'Connor MA, Fu WW, Green KA, Green WR. Subpopulations of M-MDSCs from mice infected by an immunodeficiency-causing retrovirus and their differential suppression of T- vs B-cell responses. Virology. 2015 Nov;485:263-73. doi: 10.1016/j.virol.2015.07.020. Epub 2015 Aug 27. PubMed PMID: 26318248; PubMed Central PMCID: PMC6553456.
sEstep RD, Rawlings SD, Li H, Manoharan M, Blaine ET, O'Connor MA, Messaoudi I, Axthelm MK, Wong SW. The rhesus rhadinovirus CD200 homologue affects immune responses and viral loads during in vivo infection. J Virol. 2014 Sep;88(18):10635-54. doi: 10.1128/JVI.01276-14. Epub 2014 Jul 2. PubMed PMID: 24991004; PubMed Central PMCID: PMC4178886.
O'Connor MA, Green WR. Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol. 2014 Feb;88(4):2349-53. doi: 10.1128/JVI.02960-13. Epub 2013 Dec 11. PubMed PMID: 24335302; PubMed Central PMCID: PMC3911529.
O'Connor MA, Green WR. The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression. Virol J. 2013 May 17;10:154. doi: 10.1186/1743-422X-10-154. PubMed PMID: 23680027; PubMed Central PMCID: PMC3751850.
Robinson BA, O'Connor MA, Li H, Engelmann F, Poland B, Grant R, DeFilippis V, Estep RD, Axthelm MK, Messaoudi I, Wong SW. Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection. J Virol. 2012 Mar;86(5):2769-79. doi: 10.1128/JVI.05657-11. Epub 2011 Dec 14. PubMed PMID: 22171275; PubMed Central PMCID: PMC3302252.select
Pasieka TJ, Collins L, O'Connor MA, Chen Y, Parker ZM, Berwin BL, Piwnica-Worms DR, Leib DA. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice. PLoS One. 2011;6(9):e24018. doi: 10.1371/journal.pone.0024018. Epub 2011 Sep 7. PubMed PMID: 21915277; PubMed Central PMCID: PMC3168466.lect
Estep RD, Messaoudi I, O'Connor MA, Li H, Sprague J, Barron A, Engelmann F, Yen B, Powers MF, Jones JM, Robinson BA, Orzechowska BU, Manoharan M, Legasse A, Planer S, Wilk J, Axthelm MK, Wong SW. Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection. J Virol. 2011 Sep;85(18):9527-42. doi: 10.1128/JVI.00199-11. Epub 2011 Jul 13. PubMed PMID: 21752919; PubMed Central PMCID: PMC3165757.
Brown JN, Estep RD, Lopez-Ferrer D, Brewer HM, Clauss TR, Manes NP, O'Connor M, Li H, Adkins JN, Wong SW, Smith RD. Characterization of macaque pulmonary fluid proteome during monkeypox infection: dynamics of host response. Mol Cell Proteomics. 2010 Dec;9(12):2760-71. doi: 10.1074/mcp.M110.001875. Epub 2010 Aug 24. PubMed PMID: 20736407; PubMed Central PMCID: PMC3101861.